Synergism of which cytokines play a role in fever?
1) Interleukin-1 (IL-1) and Tumor Necrosis Factor-alpha (TNF-alpha)
2) Interleukin-6 (IL-6) and Interleukin-8 (IL-8)
3) Interferon-gamma (IFN-gamma) and Interleukin-10 (IL-10)
4) Interleukin-2 (IL-2) and Interleukin-4 (IL-4)

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