The dna in skin cells is routinely bombarded by uv radiation from sunlight. This can damage the dna structure, requiring repair. What enzymes are needed for efficient repair of the damaged dna?.

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04-11-2022
Biology

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The dna in skin cells is routinely bombarded by uv radiation from sunlight. This can damage the dna structure, requiring repair. What enzymes are needed for efficient repair of the damaged dna?.

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smecloudbird18 smecloudbird18 · Answer 1 · 2022-11-10T07:42:07+01:00

Through a procedure known as nucleotide excision repair, the genetic damages caused by UV radiation are frequently repaired shortly after they are created. The lesion is recognised and excised from a section of DNA by a nuclease enzyme. After that, the ligase closes the gap and the polymerase inserts the proper bases.

Cells are shielded from UV-induced damages by DNA repair mechanisms. Nucleotide excision repair is the most significant DNA damage repair pathway involved in the excision of damages generated by UVR (such as CPDs and 6-4 PP) (NER).

DNA damages caused by UV radiation fall into two categories: 6-4 photoproducts and cyclobutene pyrimidine dimers . Both of these lesions cause bends or kinks in the DNA's structure, which prevents transcription and replication.

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