Rotenone interrupts aerobic cellular respiration by blocking electron transport in mitochondria through the inhibition of the enzyme NADH ubiquitone reductase, it also prohibit the availability of oxygen for cellular respiration.
Rotenone, a botanical pesticide, is an inhibitor of one of the enzymes of Complex I of the electron transport chain.
This insecticide, blocks electrons from NADH and stops its entry inside electron transport chain, resulting in the an inability to produce ATP from the oxidation of NADH. Rotenone acts as a strong inhibitor of complex I of the mitochondrial respiratory chain (MRC).
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